![]() In Capture One 22 (15.3), you can tether several Sony cameras over Wireless Network. Save to card & computer when tethering (Canon).As of today there is Metal support on Intel Macs, a guided tour for new users to get familiar fast, new Styles functionality, and upgrades to Capture One Live to make it more than tool for real-time collaboration, but also a post-shoot platform. It’s always rewarding to see the marks of progress, but I’d be remiss not to mention it’s also an exciting time.” – Rafael Orta, CEO, Capture Oneįurthering its commitment to development driven by user-feedback, Capture One 22 15.3 brings a host of improvements to the user experience and its current stable of features. It began with Capture One Live, and now we are moving into Capture One for iPad, with this release being a critical step into the future we are building. ![]() “In March, for the first time, we as a company shared our vision for Capture One as a multi-platform ecosystem for creatives, and laid out our roadmap for getting there it was a product of listening to our users and being ambitious for them and the community. ![]() See the full press release from Capture One (US English) belowĪ powerful update that brings all-new features and capabilities for unlimited possibilities for the modern creativeĬOPENHAGEN, June 14th, 2022: Capture One has announced the immediate availability of Capture One 22 (15.3.0), a significant and dynamic update to Capture One that brings new levels of efficiency, flexibility, and mobility for a modern and collaborative workflow.Įxtending upon its most-loved elements and features like industry-leading tethering and customizability, Capture One now introduces new favorites like wireless tethering for Sony cameras, Magic Eraser for easy and accurate masking, and Cloud Transfer the company’s major first step into multi-platform and mobile support, as it prepares for its iPad app release later this month. Wireless tethering using Capture One 22 15.3.0 with a Sony camera Capture One Pro 22 is available as a perpetual license or on subscription.Ī perpetual license is $299 upgrades from select previous generations start at $159 and subscriptions start at $20 per month.įor a complete list of all Capture One products and licensing options visit the Capture One Store. News of the 15.3.0 comes just over two months after Capture One announced the Capture One 22 15.2.0 update, which had a redesigned keystone tool and ‘substantial speed improvements’ across many of the most frequently used functions.ĭetails of Capture One 22 15.3.0 also come just over a week after Capture One revealed Capture One for iPad app will launch in late June 2022.Ĭapture One 22 (15.3.0) – availability & pricingĬapture One 22 15.3.0 is available from 14 June 2022 at 13:00 CET. The update includes wireless tethering for Sony cameras, save to card and computer when tethering with Canon cameras, a redesign of the Tool Panel, cloud transfer from iPad, Crop Ratio saved per image and Magic Eraser (to help easy, accurate masking). Capture One has announced the immediate availability of its Capture One 22 photo software (15.3.0) which is claimed to be, ‘a significant and dynamic update.’
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Continued abuse of our services will cause your IP address to be blocked indefinitely. Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here. If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior. Overusing our search engine with a very large number of searches in a very short amount of time.but its Bust-a-Move Agains music that I came to associate with the game when I first played. Using a badly configured (or badly written) browser add-on for blocking content Puzzle Bobble was a tremendous arcade hit on the Neo-Geo.Running a "scraper" or "downloader" program that either does not identify itself or uses fake headers to elude detection.Using a script or add-on that scans GameFAQs for box and screen images (such as an emulator front-end), while overloading our search engine.There is no official GameFAQs app, and we do not support nor have any contact with the makers of these unofficial apps. Continued use of these apps may cause your IP to be blocked indefinitely. ![]() This triggers our anti-spambot measures, which are designed to stop automated systems from flooding the site with traffic. Some unofficial phone apps appear to be using GameFAQs as a back-end, but they do not behave like a real web browser does.Using GameFAQs regularly with these browsers can cause temporary and even permanent IP blocks due to these additional requests. If you are using Maxthon or Brave as a browser, or have installed the Ghostery add-on, you should know that these programs send extra traffic to our servers for every page on the site that you browse. ![]() ![]() The most common causes of this issue are: Your IP address has been temporarily blocked due to a large number of HTTP requests. Oреn Shot is аlѕо good fоr clip resizing, scaling, trіmmіng, ѕnарріng, аnd rоtаtіоn, рluѕ motion рісturе сrеdіt scrolling, frame ѕtерріng, tіmе-mарріng, аudіо mixing, and real-time рrеvіеwѕ. ![]() A few оf thе ѕuрроrtеd fеаturеѕ іn thіѕ free еdіtоr іnсludеѕ dеѕktор іntеgrаtіоn fоr drаg-аnd-drор, image and audio ѕuрроrt, сurvе-bаѕеd Key Frаmе аnіmаtіоnѕ, unlimited tracks аnd layers, аnd 3D animated tіlеѕ аnd effects. You саn dоwnlоаd іt absolutely frее on nоt оnlу Wіndоwѕ and Mас but аlѕо Lіnux. 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And Roblox Hack Robux Generator – (Genuine methods 100% working) – No Human Verification ![]() The numbering will be revealed in a box near mouse cursor for the nearest surface.ĭescription and features: The most basic functionality of GMSH capability to create points, lines, surface and physical entities (that is regions or zones). In the graphical interface, select Geometry > Physical Groups > Add > Surface and then hover over each of the surfaces which are shown by the dashed gray lines. The selection of entities in GMSH using mouse key can be turned OFF and ON as shown below. In order to save an STEP geometry in native *.geo format, follow the utility File > Export. The option is to follow Geometry > Add > Volume > Select volume boundary (click on the surfaces that form a closed volume). In addition to boundary patches such as inlet, outlet and walls, fluid zone also need to be defined. ![]() Once STEP geometry is imported in GMSH, following log message is printed in console. If it is not visible, use Tools -> Message Console path or control-L command to activate / deactivate it. Progress information and messages are displayed in the bottom part of GUI in GMSH. The mesh can be generated in GMSH after setting element size as depicted below. The STEP/IGES format can be imported in GMSH using File -> Merge option. The STL geometry can be used in snappyHexMesh to generate a mesh for CFD simulation in OpenFOAM. The FreeCAD file, STEP and STL geometry can be found here: Z-Bend FreeCAD, Z-Bend geometry in STEP format and Z-Bend STL Geometry. How many of these names have you heard of? Click on the names to know more about them! In the API: gmsh::option::setNumber("Mesh.MshFileVersion", x.y). geo script: add the line Mesh.MshFileVersion = x.y for any version number x.y. In the GUI: File->Export and pick the version in the dropdown menu. ![]() Use "-format msh2 -2" command line switch while generating MSH file. As per thread on, gmshToFoam can convert only version 2 of Gmsh format. The syntax is gmshToFoam case.msh -case oFCase. The recommended method to convert a GMSH mesh to OpenFOAM format is to use utility gmshToFoam. A new variable is defined as eSize = 1e-2 and a new point can be created as Point(1) = While FreeCAD uses Python for scripting, GMSH calls its scripting language as 'affectation'. The purpose is to compile information in a place for reference to current and future users of GMSH program for learning purposes. The publisher of has not made contribution to some of the example cases included here and asserts no claim or copyright. Though it is imperative to go though all the tutorials the way the authors of this program have designed. This will help a potential user of GMSH to directly jump to the tutorial which fits his/her requirements. The information is being updated gradually, starting with a visual description of the output from each tutorial. The purpose of this web-page is to summarize the capabilities of FreeCAD and GMSH by adding user experience while running the tutorial cases. due to the point above, the command Surface Loop(3) = 0.GMSH - Open Source Meshing Program Visual Description of GMSH Tutorials.Sphere command, already creates a volume, not surfaces as you expect. ![]() “I’m here seeking justice and I’m asking my country to acknowledge what happened in Tulsa in 1921,” Fletcher, a survivor of the massacre, said.Ģ021 marks 100 years since the infamous 1921 massacre in Tulsa, in which white mobs unleashed violence against the city’s Black people, Black institutions, and Black wealth. to testify before Congress in its hearing for the centennial of Tulsa, Okla. Please follow the link (if any) and install the map theme manually.On May 19, 107-year-old Viola Fletcher visited Washington, D.C. Please use the Download Maps feature in Marble from the File menu (KDE only). See Maemo Installation (Nokia N900 only). Please install the Marble Maps package from the extras repository (the same where you installed Marble - Virtual Globe from). Marble 1.2 and later: Marble Maps package Installing Additional Map Themes Map Theme Read more about the restrictions on using Google Maps in Dennis Nienhüser's blog. We don't want to promote the usage of maps which we think are not free. Please don't add details on their installation in Marble to this Wiki. We only want to demonstrate the technical feasibility here. To the best of our knowledge the usage of these restricted maps is forbidden in an application like Marble. Make sure their terms of service allow you to use them within Marble. If you want to use these map themes, you must install them manually. The terms of service of the companies offering these maps, however, may prevent you from using it. These map themes work fine in Marble from a technical point of view. Open the Legend tab to find out which color matches which temperature. Open the Legend tab to find out which color matches which precipitation.Ĭolors indicate the average temperature in the given month. van Schagen in Amsterdam.Ī historical world map from the year 1720 created by Guillaume de L'Isle in Paris.Ī historical world map from the year 1786 created by William Faden in London.Ĭolors indicate the precipitation in the given month. Includes a very nice hillshading layer that shows the terrain (activate it in the Legend tab).Ī historical world map from the year 1689 created by G. The map is identical to that selectable in the top-right toolbox on .Ī map theme optimized for hiking and biking, based on OpenStreetMap data. In Osmarender, icon sizes are less balanced and the z-order (stacking) is wrong for some elements. On the other hand, Mapnik handles conflicting elements at the street level better. The view from space looks better than that of Mapnik. The map is identical to that selectable in the top-right toolbox on .Ĭompared to the Mapnik layer (OpenStreetMap theme), this theme has more lively colors and presents some different data. A general purpose map with useful information for the most common use cases. The map is identical to that shown on .Ĭombine this map theme with the Mercator projection for optimal speed and a sharp map view. Need to find a route? Do you like hiking or biking? Want to explore the neighborhood? Pick one of these maps. Some of them provide good country and even continent or space views, but that's not their primary area of use. These maps are optimized for high zoom levels, showing many details on the street and city level. Includes a cloud layer with real-time data.Įarth as seen from space without sun illumination. Natural Earth portrays the world environment in an idealized manner with little human influence. Includes a cloud layer with real-time data. and a height relief.Ī simple version of the Atlas theme without topography.Įarth as seen from space with sun illumination. It uses vector lines to mark coastlines, country borders etc. Map Theme Choices Overview Maps Map ThemeĪ classic topographic map. Unsure which projection to choose? A rule of thumb is to use the Spherical projection at very large distances and the Mercator projection otherwise. ![]() Safe and reliable beats vibrant and cool. Germans ordinarily pick their cars like they run their business. It’s equivalent to a car dealer selling more Volkswagen Golfs than Cadillacs while offering both cars for the same price. ![]() Nonetheless, Xing is market leader in Germany and not just by a hair. In short, LinkedIn beats Xing by miles any minute of any day. LinkedIn is the exact opposite, it’s a strong solution with numerous great features, an amazing design and concept, news posts and content all targeted for me and my professional profile. Using it is no fun and it certainly doesn’t compete with its American counterpart. It allows you to enter discussions and to specifically look for people but that’s basically it. Xing is a rather limited tool with a terrible UI and only a few features. When looking at the two it doesn’t take long to realize how different in quality those solutions are. It’s mainly operating in Germany, Austria and Switzerland where it has a total of 10 Million members. Our market leader is not an American multi-billion dollar enterprise but a local company from Hamburg called Xing. Germans might accept the American way of doing business but they’re certainly not loving it for themselves. ‚Our clocks are ticking differently‘ as we say in German. It shows the cultural discrepancies between GER and the US. Oh, it has everything to do with the issue raised. "So what does this have to do with LinkedIn?" you may ask. Asking your customer for their first name might be the most natural thing in American Starbucks stores over here, however, it's just plain awkward. ![]() Speaking of coffeehouses, Starbucks provides a good analogy. Our customer meetings have as much to do with an exciting sales call as meeting a friend at the coffeehouse has. Germans don’t trust in big words and attitude. People take their time to meet with you, they’re curious about exact functions and mechanics of your product. Here in Germany when talking to a customer, you will more likely fall asleep than have your blood boil from excitement. We’re not a country of hip startups and digital masterminds but honest hard-working people. How about German economy: Can you even name one internationally known startup? Instead, Adidas and Daimler. Or is it? When thinking about American economy it’s hard not to think of the Googles and Facebooks first. Fast and thrilling, ambitious and energetic, the way to do business with Western nations. LinkedIn puts the American way of conducting business in a nutshell: clever communication, great stories, powerful individuals and a sense for the broader picture. So why is LinkedIn lagging behind in Germany? When looking at the numbers now, one must come to the conclusion that LinkedIn doesn't exploit its full potential on this particular market. For comparison, that fraction would be at 36 % in France (9 Mio. If we calculate with five million members in Germany, only around 12 % of all economically active based in Germany would be LinkedIn members. There are 43 million economically active in Germany. Of the six million members in the D-A-CH market, Austria and Switzerland with its modern infrastructure and digital business environment provide about 15 %. Germany is both Europe’s most heavily populated country and its strongest national economy. With more than 400 million members LinkedIn is the most successful professional network in the world. Leading companies have a hard time acknowledging that their methods although successful on their home markets might not be working everywhere else. Every day corporate strategies get lost in translation when being applied to new markets. This is not a scientific study of any sort. This release adds support for Quarkus streams in the new project/module Quarkus wizard and fixes compatibilities with just released IntelliJ 2021.3. Here is the list of instances that we see for the process: QuarkXPress.exeĬ:\Program Files\Quark\QuarkXPress\QuarkXPress.exeĬ:\Program Files\Quark\QuarkXPress 8\QuarkXPress.exeĬ:\Program Files (x86)\Quark\QuarkXPress 9\QuarkXPress.exeĬ:\Program Files\Quark\QuarkXPress 9\QuarkXPress.exeĬ:\Program Files\QuarkXPress\QuarkXPress.exeĬ:\Program Files (x86)\Quark\QuarkXPress\QuarkXPress.exeĬ:\Program Files\Quark 4.01\QuarkXPress.exeį:\Programmes (f)\Quark\QuarkXPress 9\QuarkXPress.exeĬ:\Archivos de programa\Quark\QuarkXPress 8\QuarkXPress.exeĬ:\Programmi\Quark\QuarkXPress 9\QuarkXPress.exeĬ:\Program Files\Quark 4.11\QuarkXPress.exeĬ:\Program Files (x86)\Quark\QuarkXPress 8\QuarkXPress.exeĮ:\SOFTWARE.EXE\OFFICIAL TOOLS\QuarkXPress\QuarkXPress.exeĬ:\Users\username\Documents\QuarkXPress 9\QuarkXPress.exeĬ:\Newswrap\QuarkXPress 4.1\QuarkXPress.exeĬ:\Program Files\Quark 4.1\QuarkXPress.exeĬ:\Program Files\Quark\QuarkXpress8\QuarkXPress.exeĬ:\Program Files (x86)\Quark_xpress\QuarkXPress.exeĮ:\Program Files (x86)\Quark\QuarkXPress 9\QuarkXPress.exeį:\software\QuarkXPress 4.1\QuarkXPress.exeĬ:\Users\username\Desktop\QuarkXPress.exeĬ:\Program Files\Quark\QuarkXPress\QuarkXPress. We are very pleased to announce the 1.9.0 release of Quarkus Tools for IntelliJ. Free quarkxpress 9.0 download software at UpdateStar - QuarkXpress is a professional and very powerful page layout and graphic design software that lets anyone create and publish rich, compelling material for print, the web and other digital media using one easy tool. 4 QUARKXPRESS 9.0 README QUARKXPRESS 9. If you think this is a driver issue, please try Where do we see QuarkXPress.exe ? QuarkXPress 9.0 ReadMe QuarkXPress 9 offers a wealth of new features, including conditional styles, callouts, bullets and numbering, Story Editor view, and more. QuarkXPress provide options for transparency. Installers QuarkXPress Business QuarkXPress 2021 QuarkXPress 2020 Quark CopyDesk 2021 Quark CopyDesk 2020 QuarkUpdate QuarkXPress Document Converter Updaters QuarkXPress 2021 October 2021 Update (17.0.1) 2020 October 2021 Update (16.3.6) July 2021 Update (16.3.4) April 2021 Update (16.3.3): March 2021 Update (16.3.2): March 2021 Update (16.3.1): February 2021 Update (16.3): December 2020. Let try to run a system scan with Speed Up My PC to see any error, then you can do some other troubleshooting steps. All Transparencies must be flattened before submitting files to. If you encounter difficulties with QuarkXPress.exe, you can uninstall the associated program (Start > Control Panel > Add/Remove programs Let try the program named DriverIdentifier to see if it helps. Quark: App Studio, Author Web Edition, Automation Services, License Administrator, Print Collection, Publishing Platform, QuarkCopyDesk, QuarkXPress. QuarkXPress 9.0.1: QuarkXpress is a professional and very powerful page layout and graphic design software that lets anyone. ![]() Is QuarkXPress.exe using too much CPU or memory ? It's probably your file has been infected with a virus. ![]() Please take a moment to celebrate this great actress and hot lady in the “ Carla Gugino: Hottest Sexiest Photo Collection“. Gathering these photograph sessions was a pleasure in the simple fact that Carla Gugino is a natural to the camera. If you haven’t taken notice of this lovely lady, you really should! She is stunning in the adaptation of Frank Miller’s graphic novel, “Sin City” (as well as a few other noted actress in our galleries who contributed roles to this release) Of course her more noted performance lies with the much heralded film “Watchmen” where Carla played the role of “Sally Jupiter / Silk Spectre”.Ĭarla Gugino’s TV performances range the gamut of comedy, action, and horror with her mostly recent performance being 2018’s “The Haunting of Hill House” (a highly recommended Netflix worth viewing) Stand out films for Carla seem to point to the underground cult hit “Sucker Punch”, super hero films “Man of Steel” and “Batman v Superman: Dawn of Justice”. With horror genre films farther and fewer between, she still managed to take the leap with titles such as: “She Creature” and “ The Unborn” (and now TV horror shows to boot!) With later films upping the bar on cult and action hits such as: “Sin City”, “Snake Eyes”, “American Gangster” and the Jet Li starred film “The One”, she has quickly become an on-screen favorite to watch. Watch Carla Gugino Nude in Jett S01e05 2019 video on xHamster, the greatest HD sex tube site with tons of free Nudes Vimeo Nude & Celebrity Nudes porn movies. It wasn’t until 2001’s “Spy Kids” (and franchise), that we really started to take notice of this great performer. Carla’s earlier performances appeared to stay rooted in the comedy and drama genre later making the move to a more eclectic range of performances and movie styles. Now 48, her smile and good looks have always lit up a screen to go hand in hand with her talent. Discover the growing collection of high quality Most Relevant XXX movies and clips. In research it appears she has been in as many films as TV shows making for quite busy schedule over the years. Watch Carla Gugino Nude porn videos for free, here on. We are supposed to be actors, aren't we?" She laughs out loud, but you can see she's not all that amused.Carla Gugino, an actress who has been in quite a mix of films over the years, never ceases to dazzle an audience with her beauty and acting skills. Smashing nude HD porn at with new updates for any of the available videos, including for the most popular Nude video celebs Carla Gugino. It was like, 'Wait, she was a mom in Spy Kids, but a lesbian parole officer in Sin City?' It's a bizarre conundrum for people that I don't always get. "I didn't realize the effect it would have until people were becoming confused. For her star turn in the Elektra Luxx series, for example, the career brunette wears a long blond wig. It's this kind of thinking that has been Gugino's blessing and curse: Having carved out a rare niche for herself as a working character actress, she's largely disappeared into her roles, some of which were not very big to begin with. Related: The Hottest Naked Women and Nude Ladies of Esquire "The idea was that if we have a very solid piece of writing and a very small crew, and people who are all at the top of their games, we could make cool movies that you can't make in Hollywood right now." ![]() "What's cool is that all these films really started as an experiment," Gugino will later say. ¡Pronto esta nana pervertida agarra la polla de su nieto y las cosas se ponen feas ¡Dios debe mover la cabeza con fe m. Carla Crane revela sus exuberantes tetas GILF a su nieto mientras se baña. Later today she will go back to filming their latest, Hotel Noir, with Danny DeVito, Rosario Dawson, Malin Akerman, and Kevin Connolly. El borde S01E02-03 (2015) - Carla Gugino, Carla Crane revela sus exuberantes tetas GILF en la bañera. She shares the place with her longtime boyfriend, as she prefers to call him, Sebastian Gutierrez, who directed Gugino and a recurring ensemble of their beautiful and talented friends in the Elektra Luxx films, and also more recently in the full-length Web movie Girl Walks into a Bar. By sixteen she was legally emancipated, working steadily in Hollywood.Īnd now she's leading the way across the grass on gold wedges to a table in the yard of a rambling house behind a high fence that seems more fanciful than real, like the set for an adult fairy tale, art-directed by Diego Rivera. Her aunt is the iconic spokesmodel Carol Merrill from Let's Make a Deal at her urging Gugino moved to Malibu one summer and tried an acting class. While attending La Jolla High School, she was recruited into the corps of Elite Petite models. Eventually, mom remarried and settled in San Diego. Forty years old, Gugino is the daughter of an Italian orthodontist and a self-styled bohemian who fled the bonds of marriage to live for some time with her young daughter in a tepee by a river. Map showing the strategic situation on the Eastern Front in the summer of 1943. ‘Operation Citadel’, ordered by Hitler in March, was an attempt to cut off the Kursk salient with two giant pincers from north and south. The Russian post-Stalingrad advance had created a vast bulge (or salient) around the town of Kursk, jutting some 90 miles into the German lines, which, at once, provided a spearhead for the Soviet Army, or a trap should a German pincer movement succeed. In Frieser’s words, it was ‘only a preventive attack with limited aims within an overall defensive strategy.’ Hitler and the German High Command now recognised that the best that could be hoped for on the Eastern Front was stabilisation. The German Kursk offensive was not, compared with previous operations, ambitious. But it was failure to prevent the subsequent Soviet advance at Kursk that threatened German hopes of holding on to the bulk of their conquests. ![]() The battle took place some six months after the surrender of German forces at Stalingrad had dealt a massive blow to Hitler’s aim of complete victory on the Eastern Front. Was Prokhorovka really a bloody stalemate or, as has recently been argued by German historian Karl-Heinz Frieser, a clear German victory – a conclusion backed by British historian Ben Wheatley in his analysis of the photographs taken immediately after the battle by the Luftwaffe? The strategic context ![]() Both have argued that the Battle of Brody, in June 1941, involved more tanks, and was of greater importance, putting an end to Hitler’s hopes of defeating the Soviet Union in a short war. It was certainly one of the greatest tank battles of the war, but the claim that it was the greatest has been challenged by American historian David Glantz and Russian historian Valeriy Zamulin. Started by Whistling_Death_, Prokhorovka, Scout and 1 more.A rare aerial colour photo of German armour moving into action on the first morning of the Battle of Kursk. Scout Guide: Prokhorovka, South Start - 4TankersAndDog Game Discussion → General Discussion → Game Guides and Tutorials → W.o.T. Game Discussion → General Discussion → Armored Vehicle Discussion → Armored Vehicle History → Greatest Tank Battles | The Battle of Kursk: Northern Front Started by Elias_K_Grodin, challenge, kursk News and Information → News and Information → The Battle of Kursk Challenge 2021 News and Information → Wargaming Community Feedback Requests → Can we have Fiery Salient and Mittengard back in the game? ![]() Started by BeijingCornTheGhostCat, Lego, E-100, Big Tanks, WWII and 3 more. ) Mariposa Breathing planet Chasing Time For we are many Dreaming in 432 Hz"Ĭommunity Center → Community Zone → Fan Art → Large Scale Custom Lego E-100 Completed After Years of Work 672 of (It was available on YouTube, but not anymore I’m afraid.) WWII Soviets defeat Germans at Vitebsk in summer 1944 English Narration. Obedient Unto Death: A Panzer-Grenadier of the Leibstandarte- SS Adolf Hitler Reports. Decision in the Ukraine: German Panzer Operations on the Eastern Front, Summer 1943. Michael Wittmann and the Waffen SS Tiger Commanders of the Leibstandarte in World War II. ![]() (Excellent article by Ben Wheatley – you will find many aerial picture with great explanation about the battle. SS Panzer Korps and the tanks of the 5th Guards tank army". In this video you will find out more about this extraordinary battle between the Panzers of the II. But despite it’s ‘famous’ nature, not a lot is known about the actual fighting which occurred on the 12th of July 1943. "The Battle of Prokhorovka is probably the most famous tank battle of the entire Second World War. Frequently, these aims can be reached combining crucial findings, which is the case featuring the conjunction of the latest gene editing techniques and the technology capable to induce pluripotency to somatic cells through the reprogramming mechanisms. Journal reference: New England Journal of Medicine, DOI: 10.1056/NEJMoa1608368 10.Advances in medical research have always been characterized by the continuous exploration of resources able to improve and speed up the achievement of experiments designed to uncover the elements shaping a disease, with the final aim to pinpoint prognostic and diagnostic factors and above all, to identify therapeutic targets and drugs. “Be aware that if it sounds too good to be true, it may indeed not be true.” “Most legitimate research in the US does not require patients to pay for the experimental procedures,” he says, adding that people should check whether a trial has been registered with the US Food and Drug Administration. “Patients and physicians in the US should be made aware that not all ‘stem cell’ clinics are safe, and that ‘stem therapy’ as provided in private clinics in the US is unproven and potentially harmful,” says Thomas Albini at the University of Miami’s Bascom Palmer Eye Institute, Florida, who subsequently treated two of the women.Īlbini advises people to be suspicious of any procedure involving payment. Three case reports of women given such treatments for age-related macular degeneration detail how one woman went blind and the vision of the other two became much worse.Īll three ended up seeking emergency treatment in 2015, after each paid $5000 to a private clinic to receive injections of their own fatty tissue into their eyes. ![]() However, a trial of the technique in another person was cancelled in 2015, after tests revealed that the cells intended to be given to the man had developed genetic abnormalities.īut although it has taken many years to bring proven stem cell therapies to the clinic, many private centres around the world have been advertising unregulated treatments purporting to use stem cells for some time.Ī second study published today shows just how badly some unregulated treatments described as stem cell therapies can go wrong. One worry about this approach is that turning the stem cells into new tissues could lead to cancer-causing genetic mutations – though the team found no evidence of this in the treated woman. “This first iPSC-derived retinal graft is an important landmark in the field of retinal regeneration,” says James Bainbridge at University College London, and head of a trial at Moorfields Eye Hospital in London of similar grafts made instead from human embryonic stem cells. “This is a landmark study and opens the door to similar treatments for many diseases,” he says. “Takahashi and her team have done incredible work, and deserve all the praise they get for this project,” says Shinya Yamanaka, director of the Center for iPS Cell Research and Application at Kyoto University, who won the Nobel prize for inventing iPS cells and collaborated on this work. Since the graft, the woman says her vision is “brighter”. Published today, they show that the treatment hasn’t made the woman’s vision any sharper, but it does seem to have prevented further deterioration – with her vision now stable for more than two years. They then inserted the small patch of cells they had created, hoping they would become a part of her eye and stop her eyesight from degenerating. Before transplanting this into the woman’s eye in 2014, they first removed diseased tissue on her retina that was gradually destroying her sight. ![]() The researchers made a slither of cells measuring just 1 by 3 millimetres. |
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